|
KMID : 1037120190370010105
|
|
The World Journal of Men′s Health
2019 Volume.37 No. 1 p.105 ~ p.112
|
|
|
Effect of Korean Herbal Formula (Modified Ojayeonjonghwan) on Androgen Receptor Expression in an Aging Rat Model of Late Onset Hypogonadism
|
|
Choi Sae-Woong
Jeon Seung-Hwan
Kwon Eun-Bi
Zhu Guan Qun
Lee Kyu-Won
Choi Jin-Bong
Jeong Hyun-Cheol
Kim Kang-Sup
Bae Sang-Rak
Bae Woong-Jin
Kim Su-Jin
Cho Hyuk-Jin
Ha U-Syn
Hong Sung-Hoo
Hwang Sung-Yeoun
Kim Sae-Woong
|
|
|
Abstract
|
|
|
Purpose: Testosterone replacement therapy is an effective treatment for late-onset hypogonadism (LOH) despite a few contraindications and side-effects. The aim of this study was to determine whether modified Ojayeonjonghwan (KH-204, Korean herbal formula) improved LOH. KH-204 is a strong antioxidant herbal formula. We evaluated the effect of Korean herbal prescription on androgen receptor (AR) expression in an aged rat model of LOH.
Materials and Methods: Eighteen-month-old rats were used as aged LOH rat models. Eighteen Sprague-Dawley rats were randomly divided into three equal groups of six animals each and treated with one of the following: 1) normal control group (oral administration with distilled water, n=6), 2) KH-204 200 group (oral administration with 200 mg/kg of KH-204, n=6), and 3) KH-204 400 group (oral administration with 400 mg/kg of KH-204, n=6). After four weeks of treatment (once daily, distilled water or KH-204), serum testosterone levels, changes in testicular and epididymal weight, Western blotting analysis of AR expression and measurement of oxidative stress were examined.
Results: Treatment with the herbal formulation KH-204 200 mg/kg and 400 mg/kg (1) increased the weights of testis and epididymis; (2) increased the level of serum testosterone; (3) increased the level of superoxide dismutase and reduced the level of 8-hydroxy-20-deoxyguanosine; and (4) upregulated AR expression in testicular tissue.
Conclusions: KH-204 might be an effective alternative for LOH. It improves antioxidant mechanisms and increases testicular AR expression without side-effects.
|
|
|
KEYWORD
|
|
|
Hypogonadism, Phytotherapy, Receptors, androgen, Testosterone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|